AG Mittag - Molekulare Endokrinologie

Group Members

Jens Mittag (Group leader)
Rebecca Ölkrug (Postdoc)
Riccardo Dore (Postdoc)
Francesca Raffaelli (PhD student)
Mehdi Pedaran (PhD student)
Sarah Sentis (PhD student)
Nuria Lopez Alcantara (PhD student)
Julia Maier (PhD student)
Alexander Iwen (MD, leader clinical studies)
Julia Resch (Technician)
Daniela Schlatow (Financial Manager)

 

Alumni

Lisbeth Harder (former PhD student)
Sogol Gachkar (former PhD student)
Kornelia Johann (former PhD student)
Sebastian Nock (former PhD student)
Beate Herrmann (former PhD student)
Maike Byner (former MD student)

 

Reseach Interests

Our research centers around the role of thyroid hormone in the coordination of cardiovascular parameters and thermoregulatory processes. On one hand we are interested in dissecting the role of thyroid hormone on the central control of heart rate, blood pressure and brown fat thermogenesis, with a special focus on a novel population of parvalbuminergic neurons in the anterior hypothalamus. On the other hand we investigate the direct effects of thyroid hormone and its metabolites on brown fat, heart and vasculature using for instance infrared thermography, radiotelemetry and wire myography.

 

National/International Collaborations

  • Miguel Lopez (University of Santiago de Compostela, Spain)
  • Heiko Backes (Max Planck Institute for Metabolism Research, Köln)
  • Lutz Schomburg (Charité Universitätsmedizin, Berlin)
  • Anders Arner (Lund University, Sweden)

 

Selected Publications

  1. Pedaran M, Oelkrug R, Sun Q, Resch J, Schomburg L, Mittag J: "Maternal Thyroid Hormone Programs Cardiovascular Functions in the Offspring" Thyroid 2021 Aug 25; epub

  2. Oelkrug R, Mittag J: “An improved method for the precise unravelment of non-shivering brown fat thermokinetics” Scientific Reports 2021 Feb 26;11(1):4799

  3. Sentis S, Oelkrug R, Mittag J: “Thyroid hormones in the regulation of brown adipose tissue thermogenesis” Endocrine Connections 2021 Feb;10(2):R106-R115

  4. Raffaelli FM, Resch J, Oelkrug R, Iwen KA, Mittag J: „Dopamine receptor D1- and D2-agonists do not spark brown adipose tissue thermogenesis in mice” Scientific Reports 2020 Nov;10(1):20203

  5. Oelkrug R, Krause C, Herrmann B, Resch J, Gachkar S, El Gammal AT, Wolter S, Mann O, Oster H, Kirchner H, Mittag J: “Maternal brown fat thermogenesis programs glucose tolerance in the male offspring” Cell Reports 2020 Nov; 33(5):10835

  6. Herrmann B, Harder L, Oelkrug R, Chen J, Gachkar S, Nock S, Resch J, Korkowski M, Heuer H, Mittag J. "Central Hypothyroidism Impairs Heart Rate Stability and Prevents Thyroid Hormone-Induced Cardiac Hypertrophy and Pyrexia" Thyroid. 2020 Aug;30(8):1205-1216

  7. Nock S, Johann K, Harder L, Wirth EK, Renko K, Hoefig CS, Kracke V, Hackler J, Engelmann B, Rauner M, Köhrle J, Schomburg L, Homuth G, Völker U, Brabant G, Mittag J. "CD5L Constitutes a Novel Biomarker for Integrated Hepatic Thyroid Hormone Action" Thyroid. 2020 Jun;30(6):908-923

  8. Johann K, Cremer AL, Fischer AW, Heine M, Pensado ER, Resch J, Nock S, Virtue S, Harder L, Oelkrug R, Astiz M, Brabant G, Warner A, Vidal-Puig A, Oster H, Boelen A, Lopez M, Heeren J, Dalley JW, Backes H, Mittag J. “Thyroid Hormone Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption.” Cell Reports 2019 Jun 11;27(11):3385-3400

  9. Harder L, Dudazy-Gralla S, Müller-Fielitz H, Leffler JH, Vennström B, Heuer H, Mittag J: “Maternal Thyroid Hormone is Required for Parvalbumin Neuron Development in the Anterior Hypothalamic Area” Journal of Neuroendocrinology 2018 Mar;30(3):e12573

  10. Gachkar S, Oelkrug R, Martinez-Sanchez N, Rial-Pensado E, Warner A, Hoefig CS, López M, Mittag J. "3-Iodothyronamine Induces Tail Vasodilation Through Central Action in Male Mice." Endocrinology 2017 Jun 1;158(6):1977-1984

  11. Warner A, Rahman A, Solsjö P, Gottschling K, Davis B, Vennström B, Arner A, Mittag J: “Inappropriate heat dissipation ignites brown fat thermogenesis in mice with a mutant thyroid hormone receptor α1", Proceedings of the National Academy of Sciences USA 2013, Oct 1;110(40):16241-16246

  12. Mittag J, Lyons DJ, Sällström J, Vujovic M, Dudazy-Gralla S, Warner A, Wallis K, Alkemade A, Nordström K, Monyer H, Broberger C, Arner A, Vennström B. "Thyroid hormone is required for hypothalamic neurons regulating cardiovascular functions" Journal of Clinical Investigation 2013 Jan;123(1):509-16

 

Awards for AG Mittag

2021 DGE Award Best Oral Presentation Basic Science (Mehdi Pedaran)

2020 ECE Poster Award Basic Science (Mehdi Pedaran)

2020 Bruno-Allolio Award of the DGE (Beate Herrmann)

2019 Basedow Award of the DGE (Kornelia Johann)

2019 Bernd-Fischer Promotionspreis der Universität zu Lübeck (Lisbeth Harder)

2018 Wissenschaftspreis der Universität zu Lübeck (Rebecca Ölkrug)

2018 Harrington-deVisscher Award of the ETA (Jens Mittag)

2018 Basedow Award of the DGE (Lisbeth Harder)

2014 Basedow Award of the DGE (Carolin Höfig, Jens Mittag)

2012 Ernst und Berta Scharrer Award of the DGE (Jens Mittag)